Method and composition for pharmaceutical product
OwnerTerrence C. Dahl, Mark M. Menning +2inventors
InventorsTerrence C. Dahl, Mark M. Menning, Reza Oliyai, Taiyin Yang
Life of this patent
Estimating the term…
Abstract
This invention is directed to a composition comprising dry granulated tenofovir DF and emtricitabine, and a method for making same. Dry granulation was unexpectedly found to be important in preparing a tenofovir DF containing composition suitable for inclusion in a combination dosage form containing emtricitabine, efavirenz and tenofovir DF.
Claims30
A composition comprising dry granulated emtricitabine and tenofovir DF.
A method comprising granulating a composition comprising emtricitabine and tenofovir DF without contacting the composition with a destabilizing amount of liquid water.
A unitary dosage form made by a process comprising dry granulation of a composition comprising emtricitabine and tenofovir DF.
A composition comprising greater than about 75% by weight emtricitabine and tenofovir DF.
A composition comprising granules comprising tenofovir DF, emtricitabine and croscarmellose sodium in an extragranular matrix also comprising croscarmellose sodium.
Dependencies are inferred from the claim text.