Silk-based scaffold platform for engineering tissue constructs
AssigneeTufts University
InventorsLindsay Wray, Jelena Rnjak-Kovacina, David L. Kaplan
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Abstract
The inventions provided herein relate to silk-based scaffolds and methods of producing the same, which can be used for a range of tissue engineering applications. The fabrication methods described herein provide a versatile platform to incorporate hollow conduits (e.g., for nutrient/oxygen delivery) through three-dimensional silk-based scaffolds that have tunable bulk properties (e.g., but not limited to, porosity, mechanical, degradation rate) and allow endothelialization and/or cell compartmentalization, for engineering a variety of complex tissue equivalents.
Claims21
-88. (canceled)
A degradable silk scaffold system comprising:
- a porous solid-state silk matrix body;
- and
- a plurality of conduits comprising an array of linear channels arranged within the silk matrix body such that any part of the silk matrix body is spatially located from at least one conduit with a spacing that is within a diffusion limit within the range of several micrometers to about 3,000 micrometers.
Dependencies are inferred from the claim text.