Oral antimicrobial pharmaceutical compositions
AssigneeCosmo Technologies Limited
InventorsMauro AJANI, Roberta BOZZELLA, Giuseppe CELASCO, Roberto VILLA
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Abstract
The present invention relates to oral pharmaceutical compositions with controlled and/or programmed release containing at least one active ingredient having antimicrobial and/or anti-infectious activity for the treatment of infections of the large intestine, in particular the colon.
Claims49
A tablet comprising granules and at least one hydrophilic compound, wherein the granules comprise:
- (a) rifamycin SV;
- (b) at least one amphiphilic compound;
- and
- (c) at least one lipophilic compound.
A tablet coated with a gastro-resistant film, wherein the gastro-resistant film comprises methacrylic acid polymers and/or copolymers, and the tablet comprises:
- (i) a hydrophilic copolymeric substance;
- and
- (ii) granules in the hydrophilic copolymeric substance, wherein the granules comprise:
- (a) rifamycin SV;
- (b) lecithin;
- and
- (c) stearic acid.
A tablet comprising rifamycin SV, at least one amphiphilic compound, at least one lipophilic compound and at least one hydrophilic compound prepared by a process comprising the steps:
- (a) mixing rifamycin SV, at least one amphiphilic compound and at least one lipophilic compound to form a first mixture;
- (b) granulating the first mixture to form granules;
- (c) mixing the granules with at least one hydrophilic compound to form a second mixture;
- and
- (d) tableting the second mixture to form a tablet.
A tablet comprising rifamycin SV, at least one amphiphilic compound, at least one lipophilic compound and at least one hydrophilic compound prepared by a process comprising the steps:
- (a) mixing rifamycin SV and at least one amphiphilic compound to form a first mixture;
- (b) mixing the first mixture with the at least one lipophilic compound to form a second mixture;
- (c) mixing the second mixture with the at least one hydrophilic compound to form a third mixture;
- and
- (d) tableting the third mixture to form a tablet.
Dependencies are inferred from the claim text.