Novel use of angiogenin
AssigneeChung Ang University Industry Academic Cooperation Foundation
InventorsJae Chan Kim, Doo Hwan Oh, Kwang Sic Joo, Yeoun Sook Chun, Sung Wook Wee, Kyoung Woo Kim
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Abstract
The present invention provides a pharmaceutical composition for the prevention or treatment of glaucoma, wherein the pharmaceutical composition includes angiogenin or a fragment thereof as an active ingredient. Angiogenin or a fragment thereof according to the present invention activates aqueous humor outflow due to NO generation increase, Schlemm's canal expansion, and intercellular interval widening, thereby reducing intraocular pressure. Accordingly, angiogenin and a fragment may be useful for the prevention and treatment of glaucoma.
Claims18
A method of treating glaucoma, comprising:
- providing a pharmaceutical composition comprising angiogenin or a fragment thereof as an active ingredient.
A method of treating glaucoma, comprising:
- providing an ophthalmic agent comprising angiogenin or a fragment thereof as an active ingredient and additionally, an ophthalmically acceptable carrier.
A method of screening for a glaucoma treatment drug, the method comprising:
- administering a candidate drug to an animal model;
- measuring a protein level of angiogenin in a biological sample of the animal model;
- and
- comparing the protein level with a protein level of a normal animal.
A method of treating inflammatory disease, comprising:
- providing a pharmaceutical composition comprising angiogenin as an active ingredient.
Dependencies are inferred from the claim text.