Sublingual immunotherapy with reduced oral itchiness

A multi-layer tablet preparation for sublingual immunotherapy, the preparation comprising:

• a first tablet layer including a mast cell stabilizer;
• and
• a second tablet layer including an allergen suitable for sublingual immunotherapy.

A tablet preparation for sublingual immunotherapy, the preparation comprising:

• a tablet center including an allergen suitable for sublingual immunotherapy;
• and
• a tablet coating, fully enclosing the tablet center, the tablet coating including at least a mast cell stabilizer.

An apparatus for administration of sublingual immunotherapy, the apparatus comprising:

• a first squeezable ampoule of mast cell stabilizer solution;
• and
• a second squeezable ampoule of an allergen solution.

A method for administration of sublingual immunotherapy, the method comprising:

• applying sublingually a sequence of allergen doses of monotonically increasing amount;
• and
• applying sublingually, for each allergen dose of the sequence, a constant dose of mast cell stabilizer.

A stock solution of an allergen at a stock concentration mixed with Cromolyn at a concentration of 4-200 mg/ml.

A pre-filled vial of sterile water or glycerine having Cromolyn dissolved therein at a concentration of 4-200 mg/ml for use as a diluent of a stock solution also having the Cromolyn dissolved therein at a concentration of 4-200 mg/ml, the pre-filled vial being usable in a dilution sequence for sublingual immunotherapy.

A dosing system for providing sublingual immunotherapy via sublingual tablets, the dosing system comprising:

• a therapeutic sequence of sublingual tablets, the therapeutic sequence of sublingual tablets having a monotonically increasing dose of allergen, and a same dose of mast cell stabilizer in each tablet of the therapeutic sequence;
• and
• a plurality of maintenance dose sublingual tablets, each maintenance dose sublingual tablet having a same maintenance dose of allergen, and the same dose of mast cell stabilizer as in each sublingual tablet of the therapeutic sequence.

A dosing system for providing sublingual immunotherapy via sublingual ampoules, the dosing system comprising:

• a therapeutic sequence of sublingual ampoules, the therapeutic sequence of sublingual ampoules having a monotonically increasing dose of allergen, and a same dose of mast cell stabilizer in each ampoule of the therapeutic sequence;
• and
• a plurality of maintenance dose sublingual ampoules, each maintenance dose sublingual ampoule having a same maintenance dose of allergen, and the same dose of mast cell stabilizer as in each sublingual ampoule of the therapeutic sequence.

Apparatus for sequentially dispensing a therapeutic sequence of sublingual ampoules, the apparatus comprising:

• a spring-loaded magazine for dispensing joined pairs of squeezable ampoules in a sequence having monotonically increasing dose of allergen and constant dose of mast cell stabilizer;
• and
• a stack of joined pairs of squeezable ampoules in a sequence having monotonically increasing dose of allergen and constant dose of mast cell stabilizer.

A method for sublingual immunotherapy, the method comprising:

• taking a sequence of allergen tablets of monotonically increasing dose;
• and
• taking a constant sublingual dose of cromolyn 4-200 mg along with each allergen tablet of the sequence.