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US 2014/0370078 A1Published application
Topical and Transdermal Delivery of HIF-1 Modulators to Prevent and Treat Chronic Wounds
OwnerGeoffrey C. Gurtner, Jayakumar Rajadas +2inventors
InventorsGeoffrey C. Gurtner, Jayakumar Rajadas, Michael Gabriel Galvez, Evgenios Neofytou
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Abstract
Compositions and methods are provided for the prevention and treatment of chronic wounds, including, without limitation, pressure ulcers and diabetic ulcers, by transdermal delivery of an agent that increases activity of HIF-1α in the wound.
Claims25
A composition for transdermal transfer of a hydrophilic HIF-1α potentiator comprising:
- a film comprising a hydrophilic HIF-1α potentiator encapsulated in a reverse micelle with a nonionic surfactant, which reverse micelle is stabilized by polyvinylpyrrolidine (PVP) in an ethylcellulose matrix.
A method of generating a film for transdermal delivery of a hydrophilic HIF-1α potentiator comprising:
- dissolving the hydrophilic HIF-1α potentiator, a nonionic surfactant, polyvinylpyrrolidine (PVP) and ethylcellulose in a lower alcohol;
- and
- drying on a hydrophobic surface to form a film comprising the hydrophilic HIF-1α potentiator encapsulated in a reverse micelle.
Dependencies are inferred from the claim text.