Mucosal Vaccine Using Cationic Nanogel
AssigneeNational University Corporation Tokyo Medical and Dental University
InventorsKazunari Akiyoshi, Hiroshi Kiyono, Yoshikazu Yuki, Tomonori Nochi
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Abstract
A mucosal vaccine for the prevention or treatment of microbial infections is described that is capable of inducing vaccine antigen-specific immune responses in an organism without the addition of a mucosal adjuvant. The mucosal vaccine comprises a composite of a nanogel comprising a hydrophilic polysaccharide having a cationic functional group and a hydrophobic cholesterol added thereto as a side chain and a vaccine antigen. The vaccine is administered via a mucosal route.
Claims7
A method for inducing an immune response in an animal comprising transmucosally administering to the animal an immunogenic preparation comprising a composite comprising an antigen and a nanogel, wherein the nanogel comprises a hydrophilic polysaccharide having a cationic functional group, wherein a hydrophobic cholesterol is added to the hydrophilic polysaccharide as a side chain.
Dependencies are inferred from the claim text.