Adjuvant-sparing multi-dose influenza vaccination regimen
AssigneeNovartis AG
InventorsGiuseppe DEL GIUDICE, Riccardo MANETTI
Life of this patent
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Abstract
An influenza vaccine is administered by a multi-dose regimen, in which (i) a first dose is administered with an adjuvant and (ii) a later dose is administered either without an adjuvant or with a different adjuvant. Thus the invention provides the benefits of a two-dose regimen without also doubling the supply need for a given adjuvant.
Claims14
A method for immunizing a patient against influenza virus infection, comprising the steps of:
- (i) administering a dose of influenza virus vaccine comprising an inactivated influenza antigen in combination with a first adjuvant which comprises an oil-in-water emulsion;
- and
- (ii) administering a further dose of influenza virus vaccine without that adjuvant within six months after administering the dose in step (i).
A method for completing the immunization of a patient against influenza virus infection, wherein the patient has previously received a dose of influenza virus vaccine comprising an inactivated influenza antigen in combination with a first adjuvant which comprises an oil-in-water emulsion, and wherein the method comprises the step of administering to that patient a further dose of influenza virus vaccine without that adjuvant.
A kit comprising:
- (i) a first influenza virus vaccine in combination with a first adjuvant;
- and
- (ii) a second influenza virus vaccine without that adjuvant.
Dependencies are inferred from the claim text.