Compositions and methods for treating influenza
AssigneeVariation Biotechnologies Inc.
InventorsFrancisco Diaz-Mitoma, Andrei Ogrel, Jose V. Torres, David E. Anderson
Life of this patent
Estimating the term…
Abstract
The present application provides compositions and methods useful for treating influenza. As described herein, the compositions and methods are based on the development of peptides and peptide combinations which exhibit immunogenic properties against influenza. In some embodiments, the peptide combinations induce a protective response against multiple strains of influenza, e.g., seasonal strains of influenza or even the new pandemic influenza A (H1N1) virus of swine origin.
Claims199
An immunogenic composition comprising:
- a first peptide comprising a region having at least 80% homology with 20-100 contiguous amino acids of SEQ ID NO. 16, wherein the first peptide includes fewer than 100 contiguous amino acids from a type A influenza hemagglutinin protein;
- a second peptide comprising an amino acid sequence of SEQ ID NO. 17;
- and
- a third peptide comprising a region having at least 80% homology with at least 20 contiguous amino acids from positions 2-49 or 68-121 of SEQ ID NO. 18, wherein the third peptide includes fewer than 100 contiguous amino acids from a type B influenza hemagglutinin protein.
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
An immunogenic composition comprising:
- a TLR-3 agonist adjuvant;
- a vesicle which comprises a non-ionic surfactant and a transport enhancer which facilitates the transport of lipid-like molecules across mucosal membranes;
- a first peptide comprising a region having at least 80% homology with 20-100 contiguous amino acids of SEQ ID NO. 16, wherein the first peptide includes fewer than 100 contiguous amino acids from a type A influenza hemagglutinin protein;
- a second peptide comprising an amino acid sequence of SEQ ID NO. 17;
- a third peptide comprising a region having at least 80% homology with at least 20 contiguous amino acids from positions 2-49 or 68-121 of SEQ ID NO. 18, wherein the third peptide includes fewer than 100 contiguous amino acids from a type B influenza hemagglutinin protein;
- and
- a fourth peptide comprising an amino acid sequence of SEQ ID NO. 14, wherein the fourth peptide includes fewer than 20 contiguous amino acids from a type A influenza nucleoprotein.
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
An immunogenic composition comprising:
- a TLR-4 agonist adjuvant;
- a vesicle which comprises a non-ionic surfactant;
- a first peptide comprising a region having at least 80% homology with 20-100 contiguous amino acids of SEQ ID NO. 16, wherein the first peptide includes fewer than 100 contiguous amino acids from a type A influenza hemagglutinin protein;
- a second peptide comprising an amino acid sequence of SEQ ID NO. 17;
- a third peptide comprising a region having at least 80% homology with at least 20 contiguous amino acids from positions 2-49 or 68-121 of SEQ ID NO. 18, wherein the third peptide includes fewer than 100 contiguous amino acids from a type B influenza hemagglutinin protein;
- and
- a fourth peptide comprising an amino acid sequence of SEQ ID NO. 14, wherein the fourth peptide includes fewer than 20 contiguous amino acids from a type A influenza nucleoprotein.
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
Dependencies are inferred from the claim text.