COMPOSITIONS OF, AND METHODS FOR, ALPHA-1 ANTITRYPSIN FcFUSION MOLECULES
AssigneeThe Regents of the University of Colorado, a body corporate
InventorLeland SHAPIRO
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Abstract
A novel method of treating and preventing bacterial diseases is provided. In particular, the present invention relates to compositions and methods for inhibition of Gram negative, Gram positive and acid fast bacilli in general and tuberculosis (TB), mycobacterium avium complex (MAC), and anthrax in particular. Thus, the invention relates to modulation of cellular activities, including macrophage activity, and the like. More particularly, the present invention relates to the inhibitory compounds comprising naturally occurring and man-made inhibitors of serine protease.
Claims9
A pharmaceutical composition of fusion polypeptide construct comprising:
- a single alpha-1 antitrypsin fusion polypeptide comprising:
- a first polypeptide comprising mammalian alpha-1 antitrypsin (AAT);
- and
- a second polypeptide comprising an immunoglobulin constant region.
Dependencies are inferred from the claim text.