SDF-1 Binding Nucleic Acids and the Use Thereof

A method for inhibiting the migration of leukocytes, wherein the method comprises administering to a subject in need of treatment a nucleic acid that inhibits signalling between SDF-1 and the SDF-1 receptor selected from the group consisting of a type A nucleic acid, a type B nucleic acid, a type C nucleic acid, SEQ ID NO:142, SEQ ID NO:

• 143 and SEQ ID N:144,
• wherein the type A nucleic acid comprises a core nucleotide sequence:
• (SEQ ID NO:
• 19)
• 5′ AAAGYRACAHGUMAAXAUGAAAGGUARC 3′
• wherein XA is either absent or is A,
• wherein the type B nucleic acid molecule comprises a core nucleotide sequence:
• (SEQ ID NO:
• 57)
• 5′ GUGUGAUCUAGAUGUADWGGCUGWUCCUAGUYAGG 3′;
• and
• wherein the type C nucleic acid molecule comprises a core nucleotide sequence of
• (SEQ ID NO:
• 90)
• GGUYAGGGCUHRXAAGUCGG,
• wherein XA is either absent or is A.