Antibodies and pharmaceutical compositions containing same useful for inhibiting activity of metalloproteins
AssigneeYeda Research and Development Co. Ltd.
InventorsIrit SAGI, Tamar DANON
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Abstract
A method of producing a metalloprotein inhibitor, the method comprising generating antibodies directed at a composition including a metal ion-bound chelator, wherein the composition is selected having structural and electronic properties similar to a functional domain of the metalloprotein, thereby producing the metalloprotein inhibitor.
Claims14
A method of treating a disease associated with abnormal activity of a matrix metalloprotease in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of an antibody comprising an antigen recognition region which binds a transition metal ion-bound chelator, wherein the antibody inhibits an enzymatic activity of the matrix metalloprotease and wherein said antigen recognition region binds a pro-enzyme form of said matrix metalloprotease with a lower affinity than an active form of said matrix metalloprotease, thereby treating the disease.
Dependencies are inferred from the claim text.