Inhibition of macrophage-synthesized wnt7b to inhibit tumor angiogenesis and metastasis
AssigneesCincinnati Childrens's Hospital Medical Center, Albert Einstein College of Medicine of Yeshiva University
InventorsJeffrey W. Pollard, Richard A. Lang
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Abstract
The present invention provides methods of inhibiting angiogenesis in a malignant tumor, inhibiting metastasis of a malignant tumor and of inhibiting transformation of a benign tumor to a malignant tumor. The present invention also provides assays for identifying inhibitors of angiogenesis in a malignant tumor, inhibitors of metastasis of a malignant tumor and of inhibitors of transformation of a benign tumor to a malignant tumor.
Claims25
A method of inhibiting formation of blood vessels in a malignant tumor in a subject, or of inhibiting metastasis of a malignant tumor in a subject, comprising administering to the subject an inhibitor of Wnt7b in an amount effective to inhibit formation of blood vessels in a malignant tumor or metastasis of the malignant tumor in the subject, respectively.
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A method of inhibiting a benign tumor from transforming into a malignant tumor in a subject comprising administering to the subject an inhibitor of Wnt7b in an amount effective to inhibit a benign tumor from transforming into a malignant tumor.
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A method for identifying an agent as an inhibitor of angiogenesis and/or vasculogenesis in a malignant tumor or as an inhibitor of metastasis of a malignant tumor, comprising:
- contacting an amount of Wnt7b with an amount of the agent and determining whether the agent inhibits the activity of the Wnt7b,
- wherein if the agent inhibits the activity of the Wnt7b then the agent is an inhibitor of angiogenesis and/or vasculogenesis in a malignant tumor or an inhibitor of metastasis of a malignant tumor, and wherein if the agent does not inhibit the Wnt7b then the agent is not identified as an inhibitor of angiogenesis and/or vasculogenesis in a malignant tumor and/or an inhibitor of metastasis of a malignant tumor.
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Dependencies are inferred from the claim text.