Methods of Treating Pain by Inhibition of VGF Activity
AssigneeImperial Innovations Limited
InventorsKenji Okuse, Alessandro Pristera
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Abstract
The present disclosure relates to a method of treating pain, in particular neuropathic pain, comprising administering a therapeutically effective amount of an inhibitor of VGF activity resulting from binding of VGF or a peptide of the type TLQP-21 to the receptor qC1qR. The disclosure also relates to and methods of screening for said inhibitors.
Claims14
A method of treating pain, in particular neuropathic pain, comprising administering a therapeutically effective amount of an inhibitor of VGF activity resulting from binding of VGF or a peptide of the type TLQP-21 to the receptor qC1qR.
An inhibitor of VGF activity resulting from binding of VGF or a peptide of the type TLQP-21 to the receptor qC1qR, for use in treatment, in particular the treatment of pain, for example neuropathic pain.
Use of an inhibitor of VGF activity resulting from binding of VGF or a peptide of the type TLQP-21 to the receptor qC1qR, in the manufacture of a medicament for the treatment of pain, for example neuropathic pain.
An in vitro method of screening for an inhibitor of VGF mediated activity for use in the treatment of pain, in particular neuropathic pain, comprising the step of measuring the modulation (such as inhibition) of signaling through the receptor gC1q-R or binding thereto by a test agent, for example where the method comprises determining if the agent binds the receptor gC1q-R.
Dependencies are inferred from the claim text.