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US 2014/0370012 A1Published application
Fusion proteins comprising igg2 hinge domains
AssigneeGliknik Inc.
InventorsDavid Block, Henrik Olsen, Scott Strome
Life of this patent
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Abstract
The present invention relates to biologically active fusion proteins containing the IgG2 hinge as a multimerization domain capable of multimerizing proteins, peptides and small molecules which are active or more active in multimeric form; compositions comprising such fusion proteins; and methods of making and using such fusion proteins.
Claims152
A fusion protein comprising:
- one or more IgG2 hinge monomers;
- and
- one or more peptides, proteins, carbohydrates/sugars or small molecules
- wherein said one or more IgG2 hinge domains multimerizes said one or more peptides, proteins or small molecules into dimers or higher order multimers.
1 more element
The method of claim 35, wherein the steroid is prednisolone, cortisone, mometesone, testosterone, estrogen, oxandrolone, fluticasone, budesonide, beclamethasone, albuterol, or levalbuterol.
A fusion protein comprising:
- one or more IgG2 hinge monomers;
- and
- one or more Fc domains, wherein said one or more Fc domains has been engineered to comprise an antigen binding site;
- wherein said one or more IgG2 hinge domains multimerizes said one or more peptides, proteins or small molecules into dimers or higher order multimers.
1 more element
A fusion protein comprising:
- one or more IgG2 hinge monomers;
- and
- one or more antigen binding antibody variable domains, fragments or variants thereof;
- wherein said one or more IgG2 hinge domains multimerizes said one or more antigen binding antibody variable domains, fragments or variants thereof into dimers or higher order multimers.
1 more element
Dependencies are inferred from the claim text.