C-Terminally Tethered Amino Acids and Their Fibrinolytic Therapeutic Uses

Abstract

The present disclosure provides a C-terminal tethered amino acid for modulating the thrombolytic, fibrinolytic and/or anticoagulant properties of a coagulation protein. The present disclosure also provides a coagulation protein having a catalytic site modified, either at the histidine or serine residue, with the C-terminal tethered amino acid as well as therapeutic applications of those modified coagulation proteins.

Dependencies are inferred from the claim text.