Targeted antimicrobials and related compositions, methods and systems

An antimicrobial composition comprising a targeted antimicrobial protein for Bacillus Cereus or a microorganism related thereto and a suitable vehicle, the targeted antimicrobial protein having a catalytic domain and a binding domain, the targeted antimicrobial protein being BCZK2532 protein and/or a related lysin protein,

• wherein the related lysin protein has at least a 40% percentage identity with the BCZK2532 protein or a portion thereof, and
• wherein the related lysin protein has an arginine in a position corresponding upon alignment to amino acid residue 100 of BCZK2532.

An antimicrobial method comprising

• contacting a targeted antimicrobial BCZK2532 protein and/or one or more related lysin proteins with a medium suitable to host Bacillus Cereus or one or more related microorganisms, the contacting performed for a time and under condition to specifically kill or inhibit the growth of the one or more related microorganisms if present in the medium
• wherein the one or more related lysin proteins have at least a 40% percentage identity with the BCZK2532 protein or a portion thereof, and
• wherein the one or more related lysin proteins have an arginine in a position corresponding upon alignment to amino acid residue 100 of BCZK2532.