Dermaseptin b2 used as an inhibitor of the growth of a tumor
AssigneesCentre National De La Recherche Scientifique (C.N. R.S.), Universite Pierre Et Marie Curie (Paris 6), Univerité Paris est Créteil Val de Marne
InventorsJean DELBE, Mohamed AMICHE, Ali LADRAM, Cecile GALANTH, Pierre NICOLAS, Yamina HAMMA, Johanna Allegonda Anna VAN ZOGGEL, Jose COURTY
Life of this patent
Estimating the term…
Abstract
The invention relates to the use of peptides corresponding to dermaseptin B2 or fragments thereof for treating proliferative diseases such as cancer or ocular lesions, and to pharmaceutical compositions containing such peptides.
Claims13
A method for inhibiting cell growth and/or proliferation in the treatment or prevention of a proliferative disorder, an ocular lesion or an auto-immune disease in an individual, comprising the administration in a subject in need thereof of a therapeutically efficient quantity of an isolated peptide comprising or consisting of a sequence of amino acids selected from the group consisting of:
- the sequence of dermaseptin B2, the sequence of the precursor of dermaseptin B2;
- and
- a sequence of amino acids having at least 80% identity with the sequences of dermaseptin B2 or the precursor of dermaseptin B2, said sequence differing from the sequences of dermaseptin B2 or the precursor of dermaseptin B2 solely through the presence of conservative substitutions;
- provided that the peptide inhibits cell growth and/or proliferation.
Dependencies are inferred from the claim text.