Biomaterial for articular cartilage maintenance and treatment of arthritis
AssigneesChildren's Medical Center Corporation, Rhode Island Hospital
InventorsMartha M. Murray, Braden C. Fleming
Life of this patent
Estimating the term…
Abstract
The present disclosure provides biomaterials and methods for preventing and minimizing progression of cartilage and/or connective tissue damage. Also provided herein are biomaterials and methods for alleviating and/or reducing the risk for developing arthritis (e.g., osteoarthritis) associated with joint injury and/or joint surgery.
Claims28
A method for treating arthritis, comprising administering to a joint of a subject that has or is at risk for developing arthritis at the joint an effective amount of a collagen material;
- wherein the subject is not concurrently surgically treated to repair a torn, fractured, strained, bruised, or ruptured intra-articular tissue.
8-11. (canceled)
15-19. (canceled)
A method for reducing the risk for developing arthritis, comprising administering to a subject having an acute joint injury, by direct injection into a joint where the acute joint injury occurs, an effective amount of a collagen material.
(canceled)
24-25. (canceled)
28-31. (canceled)
An extracellular matrix (ECM) scaffold, comprising at least one extracellular matrix component and calcium;
- wherein the content of calcium in the ECM solution for preparing the ECM scaffold ranges from 1 mg/g to 5 mg/g.
34-37. (canceled)
39-47. (canceled)
A method for preparing a calcium-containing extracellular matrix (ECM) scaffold, comprising:
- soaking an ECM sponge in a calcium solution, wherein the ECM sponge comprises at least one ECM component and is neutralized;
- and
- lyophilizing the ECM sponge to form the calcium-containing ECM scaffold.
50-53. (canceled)
Dependencies are inferred from the claim text.