Gdf-5 mutant for inducing cartilage formation
AssigneeBiopharm Gesellschaft zur biotechnologischen Entwicklung von Pharmaka mbH
InventorsFrank Ploger, Florian Wagner
Life of this patent
Estimating the term…
Abstract
The present invention is directed to GDF-5 related proteins having an improved capability of inducing cartilage formation and a reduced capability of inducing bone formation. The novel proteins are particularly useful in the treatment of cartilage defects, wherein the formation of bone tissue is undesirable.
Claims24
1-14. (canceled)
A GDF-5-related protein, having an improved capability of inducing cartilage formation and a reduced capability of inducing bone formation, wherein the protein has an increased affinity for the BMP receptor IB (BMPR-IB) and/or a reduced affinity for the BMP receptor IA (BMPR-IA).
Dependencies are inferred from the claim text.