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US 2014/0369971 A1Published application
Method and composition for inducing human pluripotent stem cells
AssigneeThe Regents of the University of California
InventorsB. Chia Soo, Kang Ting, Zhong Zheng
Life of this patent
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Abstract
The present invention provides a fibromodulin (FMOD) reprogrammed (FReP) cell and a method of making therefor, a culture medium therefor, and a supernatant thereof, and methods of making and using these.
Claims25
A cell culture medium composition comprising:
- fibromodulin (FMOD) or a derivative or fragment thereof, wherein the composition is effective for reprogramming a cell to form a FMOD reprogrammed (FReP) cell,
- wherein the FReP cell expresses NANOG and does not form teratoma.
A method of pluripotency reprogramming, comprising:
- treating a mammalian cell with a cell culture medium comprising fibromodulin (FMOD) or a derivative or fragment thereof for a period ranging from a day to a month, and
- changing the cell culture medium regularly until a FMOD reprogrammed (FReP) cell forms;
- wherein the FReP cell expresses NANOG and does not form teratoma.
A fibromodulin (FMOD) reprogrammed (FReP) cell, generated by a method comprising:
- treating a mammalian cell with a cell culture medium for a period ranging from a day to a month, and
- changing the cell culture medium regularly until the FReP cell forms;
- wherein the medium comprises fibromodulin (FMOD) or a derivative or fragment thereof, and
- the FReP cell expresses NANOG and does not form teratoma.
1 more element
A method of inhibiting or slowing tumor growth in a subject, comprising
- administering to the subject in need thereof a composition comprising an effective amount of fibromodulin (FMOD) to a site having tumorigenic or tumor cells in the subject to cause the tumorigenic cells or tumor cells to stop growth or growing at a slower rate.
Dependencies are inferred from the claim text.