Biodegradable medical adhesive and preparation method and use thereof

A method comprising the steps of:

• uniformly mixing a mono-α-cyanoacrylate and a bis-α-cyanoacrylic acid diol ester to form a medical adhesive;
• wherein the structure of the mono-α-cyanoacrylate is represented by Formula I:
• wherein, in the Formula I,
• (1) X is an oxygen atom or a nitrogen atom, and R1 is selected from the group consisting of:
• a straight alkyl group having 1-30 carbon atoms;
• a branched alkyl group having 1-30 carbon atoms;
• a straight alkyl group having 1-30 carbon atoms substituted with an acyloxy group, a haloalkyl group, an alkoxy group, a halogen atom, a cyano group, or a combination thereof;
• a branched alkyl group having 1-30 carbon atoms substituted with an acyloxy group, a haloalkyl group, an alkoxy group, a halogen atom, a cyano group, or a combination thereof;
• a straight alkenyl group having 1-30 carbon atoms;
• a branched alkenyl group having 1-30 carbon atoms;
• a straight alkynyl group having 1-30 carbon atoms;
• a branched alkynyl group having 1-30 carbon atoms;
• a cycloalkyl group;
• an aralkyl group;
• an alkylaryl group;
• and
• an aryl group;
• (2) X is an oxygen atom, and X—R1 is a polyethylene glycol monomethyl ether (mPEG) group;
• or
• (3) X is a nitrogen atom, and X—R1 is an amino polyethylene glycol (amino PEG) group;
• and
• wherein the structure of the bis-α-cyanoacrylic acid diol ester is represented by Formula II:
• wherein, in the Formula II,
• X—R2—X represents a middle molecular fragment sandwiched between two α-cyano acryloyl moieties, and is selected from small molecule diols, polyethylene glycol (PEG), amino PEG, polylactic acid (PLA), polyglycolic acid (PGA), lactic acid-glycolic acid copolymer (PLGA), and copolymers containing polyhydroxy acid and polyglycol compounds;
• and
• X is an oxygen atom or a nitrogen atom.

A medical adhesive polymer, said medical adhesive polymer being obtained by crosslinking copolymerization of a medical adhesive under the action of anions,

• wherein the medical adhesive comprises a mono-α-cyanoacrylate and a bis-α-cyanoacrylic acid diol ester,
• wherein the structure of the mono-α-cyanoacrylate is represented by Formula I:
• wherein, in the Formula I,
• (1) X is an oxygen atom or a nitrogen atom, and R1 is selected from the group consisting of:
• a straight alkyl group having 1-30 carbon atoms;
• a branched alkyl group having 1-30 carbon atoms;
• a straight alkyl group having 1-30 carbon atoms substituted with an acyloxy group, a haloalkyl group, an alkoxy group, a halogen atom, a cyano group, or a combination thereof;
• a branched alkyl group having 1-30 carbon atoms substituted with an acyloxy group, a haloalkyl group, an alkoxy group, a halogen atom, a cyano group, or a combination thereof;
• a straight alkenyl group having 1-30 carbon atoms;
• a branched alkenyl group having 1-30 carbon atoms;
• a straight alkynyl group having 1-30 carbon atoms;
• a branched alkynyl group having 1-30 carbon atoms;
• a cycloalkyl group;
• an aralkyl group;
• an alkylaryl group;
• and
• an aryl group;
• (2) X is an oxygen atom, and X—R1 is a polyethylene glycol monomethyl ether (mPEG) group;
• or
• (3) X is a nitrogen atom, and X—R1 is an amino polyethylene glycol (amino PEG) group;
• and
• wherein the structure of the bis-α-cyanoacrylic acid diol ester is represented by Formula II:
• wherein, in the Formula II,
• X—R2—X represents a middle molecular fragment sandwiched between two α-cyano acryloyl moieties, and is selected from small molecule diols, polyethylene glycol (PEG), amino PEG, polylactic acid (PLA), polyglycolic acid (PGA), lactic acid-glycolic acid copolymer (PLGA), and copolymers containing polyhydroxy acid and polyglycol compounds;
• and
• X is an oxygen atom or a nitrogen atom;
• and
• the anions are —OH or —NH2 in blood, body fluids, tissues, skin, or a combination thereof.