Ophthalmic compositions comprising povidone-iodine
AssigneeCLS Pharmaceuticals, Inc.
InventorsC. Michael SAMSON, Bo LIANG, Joseph A. CAPRIOTTI
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Abstract
A topical ophthalmic composition comprised of povidone-iodine 0.01% to 10.0% combined with a steroid or non-steroidal anti-inflammatory drug. This solution is useful in the treatment of active infections of at least one tissue of the eye (e.g., conjunctiva and cornea) from bacterial, mycobacterial, viral, fungal, or amoebic causes, as well as treatment to prevent such infections in appropriate clinical settings (e.g. corneal abrasion, postoperative prophylaxis, post-LASIK/LASEK prophylaxis). Additionally the solution is effective in the prevention of infection and inflammation in the post-operative ophthalmic patient.
Claims43
1-44. (canceled)
A composition comprising a mixture of
- a) povidone-iodine in a concentration between 0.01% and 10% by weight, and
- b) a steroid, wherein the steroid is dexamethasone, and wherein, after a period of one week after mixing the steroid and povidone-iodine to form the composition, the available iodine concentration is not less than 6.62% of the initial available iodine concentration.
A composition comprising a mixture of
- a) povidone-iodine in a concentration between 0.01% and 10% by weight, and
- b) a steroid, wherein the steroid is dexamethasone, and wherein, wherein, after a period of one month after mixing the steroid and povidone-iodine to form the composition, the povidone-iodine concentration is at least 90% by weight of the povidone-iodine starting concentration.
Dependencies are inferred from the claim text.