Oral Care Compositions
AssigneeBrigham Young University
InventorsJoe Vazquez, Dandan Chen, Harsh M. Trivedi, Ammanuel Mehreteab, Laurence Du-Thumm, Gregory Szewczyk, Zhigang Hao
Life of this patent
Estimating the term…
Abstract
Described herein are aqueous oral compositions comprising cationic steroidal compound and a quaternary ammonium compound; and methods for making and using the same.
Claims20
An aqueous oral care composition comprising:
- a cationic steroidal compound;
- and
- a quaternary ammonium compound.
The composition of any foregoing claim, wherein cationic steroidal compound is a compound of Formula (II):
The composition of any foregoing claim, wherein the quaternary ammonium compound is selected from:
- benzalkonium chloride, benzethonium chloride, methylbenzethonium chloride, cetalkonium chloride, cetylpyridinium chloride, cetrimonium, cetrimide, dofanium chloride, tetraethylammonium bromide, didecyldimethylammonium chloride and domiphen bromide.
The composition of any foregoing claim wherein the quaternary ammonium compound comprises cetylpyridinium chloride.
The composition of any foregoing claim, wherein the cationic steroidal compound is present at a concentration of from about 0.01% to about 0.1%, by weight, of the composition.
The composition of any foregoing claim, wherein the quaternary ammonium compound is present at a concentration of from about 0.01% to about 0.1%, by weight, of the composition.
The composition of any foregoing claim, wherein the cationic steroidal compound and the quaternary ammonium compound are present in a 1:1 ratio, based on their respective concentrations, by weight, in the composition.
The composition of any foregoing claim, wherein the cationic steroidal compound is present at a concentration of about 0.05%, by weight, of the composition.
The composition of any foregoing claim, wherein the quaternary ammonium compound is present at a concentration of about 0.05%, by weight, of the composition.
The composition of any foregoing claim, further comprising a fluoride ion source;
- wherein the fluoride ion source is selected from stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluorosilicate, ammonium fluorosilicate, amine fluoride, ammonium fluoride, and a combination of two or more thereof.
A method of treating a disease or condition of the oral cavity comprising administering a composition according to any of the foregoing claims to the oral cavity of a subject in need thereof.
A method of treating an inflammatory condition of the oral cavity comprising administering a composition comprising a cationic steroidal compound to the oral cavity of a subject in need thereof.
A method of reducing volatile sulfur compounds comprising administering a composition comprising a cationic steroidal compound to the oral cavity of a subject in need thereof.
Dependencies are inferred from the claim text.