Curcumin coated magnetite nanoparticles for biomedical applications
AssigneeCouncil of Scientific and Industrial Research
InventorsAlias Joy Pattayil, Kunnoth Naduvilidam Jayaprabha
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Abstract
The present invention discloses biocompatible, stable curcumin or its derivatives coated ultra-small super paramagnetic iron oxide nanoparticles (USPION) for biomedical applications. Disclosed herein is also a simple one-pot process for the synthesis of biocompatible, stable curcumin or its derivatives coated ultra-small superparamagnetic iron oxide nanoparticles in absence of a linker or binder. The curcumin or its derivatives coated ultra-small super paramagnetic iron oxide nanoparticles of the present invention retains the medicinal, radical scavenging and fluorescence properties of curcumin.
Claims10
Curcumin coated magnetite nanoparticles comprising biocompatible, stable curcumin or its derivatives coated ultra-small super paramagnetic iron oxide nanoparticles devoid of any linker or binder, wherein the curcumin coated magnetite nanoparticles retain medicinal, radical scavenging and fluorescence properties of curcumin, for biomedical applications.
A simple one-pot process for the synthesis of curcumin coated magnetite nanoparticles, which are biocompatible, stable curcumin or its derivatives coated ultra-small superparamagnetic iron oxide nanoparticles devoid of a linker or binder, the process comprising;
- a. dissolving aqueous mixture of FeCl3.6H2O and FeCl2.4H2O in the molar ratio ranging between 1.5:1 to 2:1 in a base under inert atmosphere and stirring until complete formation and growth of magnetite nanoparticles;
- b. adding dilute mineral acid to the solution as obtained in step (a) until pH 9;
- c. adding drop wise curcumin solution dissolved in a base to the solution of step (b) under inert atmosphere, maintaining the pH 9 followed by stirring the dispersion at a temperature in the range of 50-100° C. followed by cooling;
- d. dialysing the dispersion of step (c) against water to remove excess curcumin and drying in vacuum to obtain the product.
A method for magnetic as well as fluorescent imaging and other biomedical applications, the method comprising providing curcumin coated magnetite nanoparticles, which are biocompatible, stable curcumin or its derivatives coated ultra-small iron oxide nanoparticles devoid of any linker or binder,wherein the curcumin coated magnetite nanoparticles are used as a contrast agent.
A method for delivering curcumin to a subject in need thereof comprising administering curcumin coated magnetite nanoparticles, which are biocompatible, stable, curcumin or its derivatives coated ultra-small iron oxide nanoparticles devoid of any linker or binder.
Use of curcumin coated magnetite nanoparticles, which are biocompatible, stable curcumin or its derivatives coated ultra-small iron oxide nanoparticles devoid of any linker or binder as contrast agent for magnetic as well as fluorescent imaging and other biomedical applications.
Use of curcumin coated magnetite nanoparticles, which are biocompatible, stable, curcumin or its derivatives coated ultra-small iron oxide nanoparticles devoid of any linker or binder for delivering curcumin to a subject in need thereof.
Dependencies are inferred from the claim text.