Ligands to radiation-induced molecules
AssigneeVanderbilt University
InventorsDennis E. Hallahan, Shimian Qu, Zhaozhong Han
Life of this patent
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Abstract
A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. In some embodiments, the method includes the steps of (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are targeting ligands that bind an irradiated tumor and therapeutic and diagnostic methods that employ the disclosed targeting ligands.
Claims17
A composition for guided targeting, wherein the composition comprises one or more targeting ligands comprising an amino acid sequence as set forth in Thr-Phe-Phe-Val-Ser-Thr-Arg-His-Asp-Leu-Val-Ile-Cys-Leu (SEQ ID NO:52).
A method for guided delivery of a therapeutic composition, a diagnostic composition, or a combination thereof, to a tumor in a subject, the method comprising:
- a. exposing the tumor to ionizing radiation;
- and
- b. administering to the subject a therapeutic composition, a diagnostic composition, or a combination thereof, wherein the therapeutic composition, diagnostic composition, or the combination thereof comprises a composition comprising one or more targeting ligands comprising an amino acid sequence as set forth in Thr-Phe-Phe-Val-Ser-Thr-Arg-His-Asp-Leu-Val-Ile-Cys-Leu (SEQ ID NO:52);
- whereby the therapeutic composition, diagnostic composition, or combination thereof is selectively targeted to the tumor.
A method of guided delivery of a therapeutic composition, a diagnostic composition, or a combination thereof, to a nucleus of a cell, the method comprising:
- a. exposing the cell to ionizing radiation;
- and
- b. contacting the cell with a therapeutic composition, a diagnostic composition, or a combination thereof, wherein the therapeutic composition, diagnostic composition, or the combination thereof comprises a composition comprising one or more targeting ligands comprising an amino acid sequence as set forth in Thr-Phe-Phe-Val-Ser-Thr-Arg-His-Asp-Leu-Val-Ile-Cys-Leu (SEQ ID NO:52);
- whereby the therapeutic composition, diagnostic composition, or combination thereof enters the cell and is selectively targeted to the nucleus of the cell.
Dependencies are inferred from the claim text.