Method and system for purifying charged radioisotopes
AssigneeThe Curators of the University of Missouri
InventorsCathy Sue Cutler, Gary John Ehrhardt, Hendrik Petrus Engelbrecht, Delbert E. Day
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Abstract
The present invention provides a simple and inexpensive method for removing metal and other impurities in a radioisotope solution. The invention further includes the development of a new parent/daughter generator system for collecting the daughter isotope in a concentrated solution.
Claims24
A method for generating an eluate containing daughter isotope in ionic form from a parent/daughter isotope solution, said method comprising:
- a) providing an acid-treated glass adsorbent column,
- b) providing a loading solution by adjusting the isotope solution to a pH of above about 4.0,
- c) selecting a modifier that preferentially dissolves the parent isotope over the daughter isotope and increases the activity coefficient of the daughter isotope relative to the parent isotope,
- (d) adding the modifier to the loading solution to change the dielectric properties of the loading solution and increase the activity coefficient of the daughter isotope relative to the to the parent isotope to increase selective adsorption of the daughter isotope onto the column over the parent isotope,
- d) loading the column with the loading solution,
- e) rinsing the loaded column with water to elute off the parent isotope, and
- f) eluting the daughter isotope in a solution by rinsing the column with an acid solution.
A parent/daughter generator system for providing the daughter isotope in a relatively pure and concentrated form, comprising:
- a) a reservoir containing the parent/daughter isotopes on glass spheres,
- b) a first sealed eluant vial containing a predetermined quantity of water or other solution with pH above about 4, and
- c) a second sealed eluant vial containing a predetermined quantity of an acid solution.
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Dependencies are inferred from the claim text.