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US 2014/0364294 A1Published application
Lattice loss reduction
AssigneeAcino AG
InventorsLudwig Grader, Holger Piotrowski
Life of this patent
Estimating the term…
Abstract
Methods for producing systems for the transdermal or permucosal administration of active substances and particularly transdermal therapeutic systems (TTS), wherein the active substance depots thereof have a shape that deviates from a rectangular design.
Claims32
A method for producing systems for the transdermal or permucosal administration of active substances, wherein the method comprises the following steps:
- providing a coated carrier film web (10) comprising a carrier film web (1) with an active substance-containing coating (2) adherent thereon, wherein active substance depot areas (12) are defined on the coated carrier film web (10) such that the active substance depot areas (12) are arranged in the web direction (I) of the coated carrier film web (10) in two or more rows such that the proportion of the surface of the coated carrier film web (10) that is not used as active substance depot area (12) by ignoring the rim zones of the coated carrier film web (10) is less than 39% of the total area of the coated carrier film web (10);
- and
- severing (S4) the coated carrier film web (10) in the web direction (1) into two or more sub-webs (15a, 15b, 15c, 15d) such that each sub-web contains a row of active substance depot areas (12).
A device for producing systems for the transdermal or permucosal administration of active substances comprising:
- a separating facility (230) for severing a carrier film web (10) to which an active substance-containing coating (2) is applied in adherent manner into two or more sub-webs (15a, 15b, 15c, 15d) that at least partially laterally engage with one another,
- an offset facility (240) designed to change the location of the sub-webs (15a, 15b, 15c, 15d) relative to each other such that none of the sub-webs laterally engages one of the other sub-webs.
Dependencies are inferred from the claim text.