Terpene analogues and uses thereof for treating neurological conditions

A composition for treating a neurological condition, comprising a terpene analogue of Formula 1:

• wherein:
• Y is a substituted or unsubstituted C1 to C20 alkylene, C═O, SO, SO2, or absent;
• X is H, OR1, N—(R2)2, a substituted or unsubstituted C1 to C20 alkyl, or a substituted or unsubstituted heterocyclyl (for example, heteroaryl), wherein when Y is absent X is not H;
• R1 is H, a substituted or unsubstituted C1 to C20 alkyl, or a substituted or unsubstituted CH2-aryl;
• each R2 is independently H, a substituted or unsubstituted C1 to C20 alkyl, aryl, OR1, CN or C(═O)—R3;
• R3 is a substituted or unsubstituted C1 to C20 alkyl, or a substituted or unsubstituted aryl;
• W is H, a substituted or unsubstituted C1 to C20 alkyl, or a substituted or unsubstituted aryl;
• and
• Z is a substituted or unsubstituted C1 to C20 alkylene;
• or a pharmaceutically acceptable isomer, salt or ester thereof, and,
• optionally, a pharmaceutically acceptable diluent or carrier.

Use of a terpene analogue of Formula 1:

• wherein:
• Y is a substituted or unsubstituted C1 to C20 alkylene, C═O, SO, SO2, or absent;
• X is H, OR1, N—(R2)2, a substituted or unsubstituted C1 to C20 alkyl, or a substituted or unsubstituted heterocyclyl (for example, heteroaryl), wherein when Y is absent X is not H;
• R1 is H, a substituted or unsubstituted C1 to C20 alkyl, or a substituted or unsubstituted CH2-aryl;
• each R2 is independently H, a substituted or unsubstituted C1 to C20 alkyl, aryl, OR1, CN or C(═O)—R3;
• R3 is a substituted or unsubstituted C1 to C20 alkyl, or a substituted or unsubstituted aryl;
• W is H, a substituted or unsubstituted C1 to C20 alkyl, or a substituted or unsubstituted aryl;
• and
• Z is a substituted or unsubstituted C1 to C20 alkylene;
• or a pharmaceutically acceptable isomer, salt or ester thereof,
• for treating a neurological condition in a subject in need thereof.