Swine genetically modified with specificity for ldl-r knockout
AssigneeRecombinetics, Inc.
InventorsScott C Fahrenkrug, Daniel F Carlson
Life of this patent
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Abstract
Compositions and methods for swine LDL-R gene knockouts.
Claims21
A method of making a genetically modified swine comprising exposing a primary cell in vitro or an embryo to a target-specific nuclease that specifically binds to an LDL-R gene.
A genetically modified swine comprising a genomic knockout of a low density lipoprotein receptor (LDL-R) gene.
A cell or an embryo comprising a nucleic acid fragment encoding a targeted nuclease and a genetic modification at a DNA site that is specifically bound by the targeted nuclease, wherein the cell comprises a primary cell isolated from an animal tissue, and wherein the cell and the embryo are chosen from the group consisting of artiodactyls, swine, bovine, fish, rabbit, and livestock.
Dependencies are inferred from the claim text.