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US 2014/0350680 A1Published application
Process for modifying the surface morphology of a medical device
OwnerDang Quang Svend Le, Muwan Chen +7inventors
InventorsDang Quang Svend Le, Muwan Chen, Menglin Chen, Anette Overgaard Baatrup, Cody Eric Bünger, Helle Lysdahl, Jørgen Kjems, Morten Østergaard Andersen, Flemming Besenbacher
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Abstract
The present invention relates to a process for modifying the surface morphology of a medical device. The modified surface has, among other advantageous properties, an improved capacity for sorption or conjugation of a variety of bioactive agents, the addition of which will turn the medical device into a localized drug delivery system.
Claims33
A method for modifying a surface morphology of a medical device comprising:
- a) providing a medical device comprising a bulk part and a surface region, wherein said surface region comprises a biocompatible polymeric composition comprising a biocompatible polymer;
- b) contacting at least a portion of the biocompatible polymeric composition in said surface region with a solvent of the biocompatible polymer to form a first surface region film on at least a first part of said surface region;
- c) contacting at least a part of said first surface region film with a non-solvent of said biocompatible polymer, thereby forming a first solidified surface region film on at least a part of said surface region;
- and
- d) subjecting the first solidified surface region film to a hydrolytic treatment.
2 more elements
2-34. (canceled)
Dependencies are inferred from the claim text.