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US 2014/0350472 A1Published application
Dissolvable microneedle arrays for transdermal delivery to human skin
AssigneesUniversity of Pittsburgh—Of the Commonwealth System of Higher Education, Carnegie Mellon University
InventorsLouis D. Falo, JR., Geza Erdos, O. Burak Ozdoganlar
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Abstract
A method of forming a microneedle array can include forming a sheet of material having a plurality of layers and micromilling the sheet of material to form a microneedle array. At least one of the plurality of layers can include a bioactive component, and the microneedle array can include a base portion and plurality of microneedles extending from the base portion.
Claims16
A method of forming a microneedle array, comprising:
- forming a sheet of material having a plurality of layers, at least one of the plurality of layers comprising a bioactive component;
- and
- micromilling the sheet of material to form a microneedle array, the microneedle array comprising a base portion and plurality of microneedles extending from the base portion.
A method comprising:
- forming a sheet of material having a plurality of layers, at least one of the plurality of layers comprising a bioactive component;
- and
- removing portions from the sheet of material until a microneedle array is formed having a base portion and plurality of microneedles extending from the base portion,
- wherein the removal of portions from the sheet array comprises forming the microneedle array so that each microneedle comprises a first cross-sectional dimension at a top portion, a second cross-sectional area at a bottom portion, and a third cross-sectional dimension at an intermediate portion, the intermediate portion being located between the top portion and the bottom portion, and the third cross-sectional dimension being greater than the first and second cross-sectional dimensions.
1 more element
Dependencies are inferred from the claim text.