Hemostatic compositions and uses therefor
AssigneeMarine Polymer Technologies, Inc.
InventorsJohn N. Vournakis, Sergio Finkielsztein
Life of this patent
Estimating the term…
Abstract
The present invention relates generally to the field of hemostasis, including methods, compositions, and devices that can be employed to achieve hemostasis at an increased rate. More specifically the present invention relates to hemostatic compositions that achieve a hemostatic effect at a distance from the site of application of the composition, and a method for administering such a composition to effectively reduce localized vascular complications associated with treating a breach or puncture in a vein or artery and reduce the time to achieve hemostasis.
Claims41
A method for treating a puncture in a vein or artery resulting from a cardiac catheterization procedure in a patient, comprising:
- a) applying topically to the patient's skin over a catheter exit site a composition comprising an effective amount of a vasoconstrictor, wherein the vasoconstrictor does not comprise a poly-β-1→4 N-acetylglucosamine polymer or derivative thereof, and wherein the catheter exit site is contiguous with the catheter puncture in the vein or artery by 1-10 cm;
- and concurrently
- b) applying compression to the punctured vein or artery,
- wherein a cessation or reduction of blood flow out of the breach or puncture in the vein or artery is achieved in 30%-50% less time than applying compression in conjunction with a topical barrier-forming material without said vasoconstrictor.
A method for treating a puncture in a femoral artery resulting from a cardiac catheterization procedure in a patient, comprising:
- a) applying topically to the patient's skin over a catheter exit site a composition comprising an effective amount of a vasoconstrictor, wherein the vasoconstrictor does not comprise a poly-β-1→4 N-acetylglucosamine polymer or derivative thereof, and wherein the catheter exit site is contiguous with the catheter puncture in the femoral artery by 1-10 cm;
- and concurrently
- b) applying compression to the punctured vein or artery,
- wherein a cessation or reduction of blood flow out of the breach or puncture in the femoral artery is achieved in 30%-50% less time than applying compression in conjunction with a topical barrier-forming material without said vasoconstrictor.
A method for inhibiting the formation of hematomas resulting from a cardiac catheterization procedure in a patient, comprising:
- a) applying topically to the patient's skin over a catheter exit site contiguous by 1-10 cm with a catheter puncture in a vein or artery a composition comprising an effective amount of a vasoconstrictor, wherein the vasoconstrictor does not comprise a poly-β-1→4 N-acetylglucosamine polymer or derivative thereof;
- b) concurrently applying compression to the punctured vein or artery;
- and
- c) recording the number of hematomas formed,
- wherein the formation of hematomas is inhibited in comparison to applying compression in conjunction with a topical barrier-forming material without said vasoconstrictor.
A method for decreasing the occurrence of localized vascular complications comprising:
- a) applying topically to the patient's skin over a wound contiguous with a breach or puncture in a vein or artery a composition comprising a vasoconstrictor, wherein the vasoconstrictor does not comprise a poly-β-1→4 N-acetylglucosamine polymer or derivative thereof;
- b) concurrently applying compression to the breached or punctured vein or artery;
- and
- c) recording the occurrence of localized vascular complications,
- wherein an amount of the vasoconstrictor is effective to cause sealing of the breach or puncture in the vein or artery, reducing the rate of localized vascular complications in comparison to applying compression in conjunction with a topical barrier-forming material without a vasoconstrictor.
Dependencies are inferred from the claim text.