Localized Physiologic Status From Luminosity Around Fingertip Or Toe
AssigneeEPIC Research & Diagnostics, Inc.
InventorNancy R. Rizzo
Life of this patent
Estimating the term…
Abstract
Spatial light response around a fingertip or toe of a subject in response to electrical stimulation can be associated to a specified remote particular body anatomy, location, component, or system such as for providing a particularized physiological status indicator or other particularized response indication that is particular to the specified particular body anatomy, location, component, or system.
Claims26
(canceled)
The apparatus of any one of claims 9, 19, 22, 23, or 24, wherein the signal processor circuit is configured such that the particularized response indication indicates a relative risk of an abnormal physiological state of the specified particular body anatomy, location, component, or system relative to at least one of (1) at least one other particular body anatomy, location, component, or system or (2) a normal physiological state of the specified particular body anatomy, location, component, or system.
The apparatus of any one of claims 9, 19, 22, 23, or 24, wherein the signal processor circuit is configured such that the at least 21 two-dimensional spatial response information is pre-processed, before computing the plurality of parameters, to attenuate or ignore one or more spatial response artifacts within at least one designated area of the at least two-dimensional spatial response information.
The apparatus of any one of claims 9, 19, 22, 23, or 24, wherein the signal processor circuit is configured such that the at least two-dimensional spatial response information is pre-processed, before computing the plurality of parameters, to automatically orient the at least two-dimensional spatial response information at least one of rotationally or translationally.
5-8. (canceled)
An apparatus comprising:
- a signal processor circuit, configured to:
- obtain at least two-dimensional spatial response information of visible or other light around a finger or toe of a subject, the spatial response information obtained at a light detector configured to be capable of providing information regarding at least first and second spatial dimensions that are orthogonal to each other, the light obtained in response to electrical stimulation of the finger or toe sufficient to produce the light around the finger or toe;
- and
- associate the spatial response information to a specified particular body anatomy, location, component, or system that is remote from the finger or toe at which the spatial response information was obtained, the associating including:
- radially sectoring the at least two-dimensional spatial response information;
- computing a plurality of parameters, including using the radially sectored at least two-dimensional spatial response information to compute at least one of the parameters;
- adjusting or comparing at least one of the parameters using information from a clinical knowledge base representative of a population of patients including using at least some patients other than the subject;
- and
- using the at least one adjusted parameter for using the spatial response information for providing a particularized response indication that is particular to the specified particular body anatomy, location, component, or system;
- an electrode, configured to provide the electrical stimulation to the finger or toe;
- wherein
- the electrical stimulation includes AC electrical stimulation, the electrode is transparent enough to pass at least a portion of the visible or other light around the finger or toe;
- the light detector is configured to receive through the electrode the passed portion of the visible or other light around the finger or toe;
- and
- the light detector is configured to provide to the signal processor circuit the two-dimensional spatial response information of visible or other light around the finger or toe;
- and
- a dielectric barrier, between (1) the finger or toe of the subject and (2) the electrode, wherein the dielectric barrier is configured to be transparent enough to pass the portion of the visible or other light around the finger or toe;
- wherein the particularized response indication is exclusive to the specified particular body anatomy, location, component, or system, and is exclusive of other particular body anatomy, locations, components, or systems;
- wherein the associating further includes computing the particularized response indication using both at least two-dimensional spatial light intensity aggregate and density information;
- and
- wherein the spatial response information includes a first at least two-dimensional spatial response information and a second at least two-dimensional spatial response information, and wherein the associating includes computing the particularized response indication using differential or other relative information determined between (1) the first spatial response information, obtained with the presence of a dielectric barrier between the finger or toe and the electrode;
- and (2) the second spatial response information, obtained without the presence of the dielectric barrier between the finger or toe and the electrode.
The apparatus of any one of claims 9, 19, 22, 23, or 24, wherein the signal processor circuit is configured to determine the particularized response indication including trending over time both at least two-dimensional spatial light intensity aggregate and density information.
The apparatus of any one of claims 9, 19, 22, 23, or 24, wherein the signal processor circuit is configured to determine the particularized response indication using a polynomial relationship of an area and an average intensity of spatial light intensity information.
The apparatus of any one of claims 9, 19, 22, 23, or 24, wherein the signal processor circuit is configured to:
- determine a physiological status indicator using the particularized response information;
- and
- provide the physiological status indicator to a user or automated process.
The apparatus of any one of claims 9, 19, 22, 23, or 24, wherein the signal processor circuit is configured to use the spatial response information for providing a particularized response indication that is particular to a selected particular one of:
- a cardiovascular system, a gastrointestinal/endocrine system, a respiratory system, a renal system, or a hepatic system.
The apparatus of any one of claims 9, 19, 22, 23, or 24, wherein the signal processor circuit is configured to use the spatial response information for providing a physiological status indicator that is particular to a selected particular one of:
- a cardiovascular system, a gastrointestinal/endocrine system, a respiratory system, a renal system, or a hepatic system.
The apparatus of any one of claims 9, 19, 22, 23, or 24, wherein the signal processor circuit is configured to use the spatial response information for providing a particularized response indication including using a determining of an Entropy parameter of the spatial response information.
The apparatus of any one of claims 9, 19, 22, 23, or 24, wherein the signal processor circuit is configured to use the spatial response information for providing a particularized response indication including determining a Form-One parameter of the spatial response information that is within a specified centered first annulus region between an inner first radius of the annulus and an outer second radius of the annulus.
The apparatus of any one of claims 9, 19, 22, 23, or 24, wherein
- the signal processor circuit is configured to use the spatial response information for providing a particularized response indication including determining a Form-One parameter of the spatial response information that is within a specified centered first annulus region between an inner first radius of the annulus and an outer second radius of the annulus;
- and
- the signal processor circuit is configured to use the spatial response information for providing the particularized response indication including also determining a Form-Two parameter of the spatial response information that is within a specified centered second annulus region between the inner first radius of the annulus and an outer third radius of the annulus, wherein the third radius exceeds the second radius.
The apparatus of any one of claims 9, 19, 22, 23, or 24, wherein the signal processor circuit is configured to use the spatial response information for providing the particularized response indication including determining a Fractal parameter of the spatial response information using (1) a perimeter of spatial response pixels exceeding a specified threshold value and (2) a spatial variation in the perimeter of spatial response pixels exceeding the specified threshold value.
An apparatus comprising:
- a signal processor circuit, configured to:
- obtain at least two-dimensional spatial response information of visible or other light around a finger or toe of a subject, the spatial response information obtained at a light detector configured to be capable of providing information regarding at least first and second spatial dimensions that are orthogonal to each other, the light obtained in response to electrical stimulation of the finger or toe sufficient to produce the light around the finger or toe;
- and
- associate the spatial response information to a specified particular body anatomy, location, component, or system that is remote from the finger or toe at which the spatial response information was obtained, the associating including:
- radially sectoring the at least two-dimensional spatial response information;
- computing a plurality of parameters, including using the radially sectored at least two dimensional spatial response information to compute at least one of the parameters;
- adjusting or comparing at least one of the parameters using information from a clinical knowledge base representative of a population of patients including using at least some patients other than the subject;
- and
- using the at least one adjusted parameter for using the spatial response information for providing a particularized response indication that is particular to the specified particular body anatomy, location, component, or system;
- wherein the spatial response information includes a first at least two-dimensional spatial response information and a second at least two-dimensional spatial response information, and wherein the signal processor circuit is configured to use the spatial response information for providing a particularized response indication including using first differential information determined between (1) the first spatial response information, obtained with the presence of a dielectric barrier between the finger or toe and the electrode;
- and (2) the second spatial response information, obtained without the presence of the dielectric barrier between the finger or toe and the electrode;
- and
- wherein the spatial response information further includes a third at least two-dimensional spatial response information and a fourth at least two-dimensional spatial response information, and wherein the signal processor circuit is configured to use the spatial response information for providing a particularized response indication further including using second differential information determined between (1) the third spatial response information, obtained as a calibration spatial response with the presence of a dielectric barrier between the finger or toe and the electrode;
- and (2) the fourth spatial response information, obtained as a calibration image without the presence of the dielectric barrier between the finger or toe and the electrode.
An apparatus comprising:
- a signal processor circuit, configured to:
- obtain at least two-dimensional spatial response information of visible or other light around a finger or toe of a subject, the spatial response information obtained at a light detector configured to be capable of providing information regarding at least first and second spatial dimensions that are orthogonal to each other, the light obtained in response to electrical stimulation of the finger or toe sufficient to produce the light around the finger or toe;
- and
- associate the spatial response information to a specified particular body anatomy, location, component, or system that is remote from the finger or toe at which the spatial response information was obtained, the associating including:
- radially sectoring the at least two-dimensional spatial response information;
- computing a plurality of parameters, including using the radially sectored at least two-dimensional spatial response information to compute at least one of the parameters;
- adjusting or comparing at least one of the parameters using information from a clinical knowledge base representative of a population of patients including using at least some patients other than the subject;
- and
- using the at least one adjusted parameter for using the spatial response information for providing a particularized response indication that is particular to the specified particular body anatomy, location, component, or system;
- wherein the spatial response information includes a first spatial response information and a second spatial response information, and wherein the signal processor circuit is configured to use the spatial response information for providing a particularized response indication including computing the particularized response indication using a Reference-Subjective parameter determined from (1) a composite intensity and (2) a spatial extent of active pixels, as determined for each of (1) the first spatial response information, obtained with the presence of a dielectric barrier between the finger or toe and the electrode;
- and (2) the second spatial response information, obtained without the presence of the dielectric barrier between the finger or toe and the electrode.
An apparatus comprising:
- a signal processor circuit, configured to:
- obtain at least two-dimensional spatial response information of visible or other light around a finger or toe of a subject, the spatial response information obtained at a light detector configured to be capable of providing information regarding at least first and second spatial dimensions that are orthogonal to each other, the light obtained in response to electrical stimulation of the finger or toe sufficient to produce the light around the finger or toe;
- and
- associate the spatial response information to a specified particular body anatomy, location, component, or system that is remote from the finger or toe at which the spatial response information was obtained, the associating including:
- radially sectoring the at least two-dimensional spatial response information;
- computing a plurality of parameters, including using the radially sectored at least two-dimensional spatial response information to compute at least one of the parameters;
- adjusting or comparing at least one of the parameters using information from a clinical knowledge base representative of a population of patients including using at least some patients other than the subject;
- and
- using the at least one adjusted parameter for using the spatial response information for providing a particularized response indication that is particular to the specified particular body anatomy, location, component, or system;
- wherein the signal processor circuit is configured to use the spatial response information for providing a particularized response indication including computing the physiological status indicator using a Reference-Subjective parameter determined from (1) a composite intensity and (2) a spatial extent of active pixels.
An apparatus comprising:
- a signal processor circuit, configured to:
- obtain at least two-dimensional spatial response information of visible or other light around a finger or toe of a subject, the spatial response information obtained at a light detector configured to be capable of providing information regarding at least first and second spatial dimensions that are orthogonal to each other, the light obtained in response to electrical stimulation of the finger or toe sufficient to produce the light around the finger or toe;
- and
- associate the spatial response information to a specified particular body anatomy, location, component, or system that is remote from the finger or toe at which the spatial response information was obtained, the associating including:
- radially sectoring the at least two-dimensional spatial response information;
- computing a plurality of parameters, including using the radially sectored at least two-dimensional spatial response information to compute at least one of the parameters;
- adjusting or comparing at least one of the parameters using information from a clinical knowledge base representative of a population of patients including using at least some patients other than the subject;
- and
- using the at least one adjusted parameter for using the spatial response information for providing a particularized response indication that is particular to the specified particular body anatomy, location, component, or system;
- wherein the signal processor circuit is configured to:
- sample the spatial response information repeatedly over sampling period of interest at a sampling rate exceeding twice a frequency bandwidth of a parameter of interest;
- determine a frequency characteristic of the parameter of interest;
- and
- determine a physiological status indication using the frequency characteristic of the parameter of interest.
26-51. (canceled)
Dependencies are inferred from the claim text.