Back to results
US 2014/0350262 A1Published application
Reactivators Of Organophosphorous Inhibited Acetylcholinesterase
AssigneeSouthwest Research Institute
InventorsWilliam E. BAUTA, William R. CANTRELL, JR., Michael W. TIDWELL
Life of this patent
Estimating the term…
Abstract
The present invention relates to organophosphate-inhibited acetylcholinesterase (AChE) reactivators with central nervous system (CNS) bioavailability and their associated methods of preparation including their use for treatment of exposure to AChE inhibitors such as an organophosphate (OP) insecticides and nerve agents.
Claims14
An acetylcholinesterase reactivator comprising the formula:
- wherein R1 is a ketone functionality (C(O)R) or hydrogen and R may be a H or an alkyl group containing up to five carbon atoms;
- R2 is a hydrogen or an alkyl group containing up to five carbon atoms;
- R3 may be H or an electron withdrawing group or electron donating group;
- Y may be a carbon or nitrogen;
- and
- n has a value of 0-4.
3 more elements
Canceled
A cholinesterase reactivator comprising the formula:
- wherein R1 is a ketone functionality (C(O)R) or hydrogen and R may be a H or an alkyl group containing up to five carbon atoms;
- R2 and R4 are hydrogen or an alkyl group containing up to five carbon atoms;
- R3 may be H or an electron withdrawing group or electron donating group;
- Y may be a carbon or nitrogen;
- and
- n has a value of 0-4.
3 more elements
4-18. (canceled)
Dependencies are inferred from the claim text.