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US 2014/0350260 A1Published application
Heterocyclic compound and use thereof
AssigneeTakeda Pharmaceutical Company Limited
InventorsTatsuki KOIKE, Minoru Nakamura, Yoshihide Tomata, Takafumi Takai, Yasutaka Hoashi, Yuichi Kajita, Tetsuya Tsukamoto, Makoto Kamata
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Abstract
The present invention provides a heterocycle derivative having a superior amyloid β production inhibitory activity and/or a superior γ-secretase modulation activity, and use thereof. A compound represented by the formula (I): wherein each symbol is as defined in the present specification, or a salt thereof.
Claims23
A compound represented by the formula (I):
- wherein
- ring A is an optionally substituted oxazole ring, an optionally substituted triazole ring, an optionally substituted imidazole ring, an optionally substituted pyridine ring, or an optionally substituted pyrazole ring,
- ring B is an optionally substituted benzene ring, an optionally substituted pyridine ring, or an optionally substituted pyrimidine ring, and
- partial structure (1):
- is
- wherein
- R1 and R2 are the same or different and each is a substituent,
- L is a bond, —Y—, —O—, —YO—, —OY—, —S—, —SO—, —SO2—, —CONRa—, —NRaCO—, —NRa—, —YNRa—, —NRaY—, —YCONRa—, —NRaCOY—, —OCONRa—, —NRaCOO— or —NRbCONRa—
- wherein
- Y is an optionally substituted C1-6 alkylene group,
- Ra is a hydrogen atom or an optionally substituted C1-6 alkyl group,
- Rb is a hydrogen atom or an optionally substituted C1-6 alkyl group,
- R3 is a substituent, and
- n is an integer of 0-6,
- provided that 2-{(8R)-3-[3-Methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-8-(3,4,5-trifluorophenoxy)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-8-yl}propan-2-ol is excluded,
- or a salt thereof.
13 more elements
(canceled)
20-23. (canceled)
26-29. (canceled)
Dependencies are inferred from the claim text.