Process for the preparation of vilazodone or its pharmaceutically acceptable salts
AssigneeRanbaxy Laboratories Limited
InventorsPrasenjit Prafulla Das, Bindu Srivastava, Nitin Maheshwari, Hashim Nizar Poovanathil Nagoor Meeran, Mohan Prasad, Sudershan Kumar Arora
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Abstract
The present invention relates to a process for the preparation of vilazodone or its pharmaceutically acceptable salts. The present invention further provides a crystalline form of vilazodone free base.
Claims19
A process for the preparation of 5-{4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl}-1-benzofuran-2-carboxamide of Formula I
- or its pharmaceutically acceptable salts which comprises:
- a) reacting 3-(4-chlorobutyl)-1H-indole-5-carbonitrile of Formula II
- with 5-(piperazin-1-yl)-1-benzofuran-2-carboxamide of Formula III,
- in the presence of a base and a solvent;
- b) isolating the compound of Formula I from the reaction mixture thereof;
- and
- c) optionally converting the compound of Formula I to its pharmaceutically acceptable salts.
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A crystalline form of vilazodone free base with substantially the same XRPD (X-Ray Powder Diffraction Pattern) as depicted in FIG. 1 or FIG. 2.
A crystalline form of vilazodone free base characterized by an XRPD having interplanar spacing (d) values substantially at 6.41, 5.14, 4.79, 4.43, 4.27, 4.17, 4.06, and 3.69±0.2 Å.
Dependencies are inferred from the claim text.