Chemical entities and therapeutic uses thereof

A compound of Formula I

• and pharmaceutically acceptable salts thereof, wherein
• W1 is CR6, CHR6, NR6, or N;
• W2 is CR7, N, or NR7;
• W3 is CR2, CHR2, N, or NR2;
• W4 is CR11 or N;
• W5 is C(O), CHR3, or CR3;
• and no more than two adjacent ring atoms are N or NR7;
• R1 is hydrogen, amino, alkyl, alkoxy, aryl, heteroaryl, or cyano;
• R2 is hydrogen, halo, amino, alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl or X;
• R3 is hydrogen, amino, alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or X;
• R4 is hydrogen and R5 is hydrogen, alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, amino, alkoxycarbonyl, or acyl;
• or R4 and R5, taken together with any intervening atoms, form a heteroaryl ring;
• R6 is hydrogen, halo, amino, alkoxy, lower alkyl, cyano, or X when W1 is CR6 or CHR6;
• or R6 is hydrogen or lower alkyl when W1 is NR6;
• R7 is hydrogen, halo, lower alkyl, or aryl when W2 is CR7;
• or R7 is hydrogen, lower alkyl, or aryl when W2 is NR7;
• or R7 and R3, taken together with any intervening atoms, form a cycloalkyl, heterocycloalkyl, or heteroaryl ring;
• R8 and R9 are independently hydrogen, alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl, or R8 and R9 taken together with any intervening atoms, form a heterocycloalkyl ring;
• R10 is hydrogen, alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
• R11 is hydrogen, alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or X;
• or R11 and R5 taken together with any intervening atoms, form a heterocycloalkyl or heteroaryl ring;
• and
• X is —C(O)NR8R9, —SO2NR8R9, —NHC(O)NR8R9, or —NR8C(O)R10.