Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors

A compound of Formula I or II

• enantiomers, diastereomers, and salts thereof wherein
• W and X are independently CH or N;
• A1 and A2 together with ring carbon atoms to which they are attached combine to form benzene, cyclopentadiene, pyridine, pyridone, pyrimidine, pyrazine, pyridazine, 2H-pyran, pyrrole, imidazole, pyrazole, triazole, furan, oxazole, isoxazole, oxadiazole, thiophene, thiazole, isothiazole or thiadiazole any of which may be optionally partially saturated, and any of which may be optionally independently substituted with one or more Rx groups as allowed by valence;
• B1 and B2 together with the ring atoms to which they are attached combine to form dihydropyridine, dihydropyridone, dihydropyrimidine, dihydropyrimidone, dihydropyrazine, dihyrdopyridazine, pyrrole, imidazole, pyrazole, triazole, or tetrazole any of which may be optionally partially saturated, and any of which may be optionally independently substituted with one or more Rx groups as allowed by valence;
• R1 is —Y-(alkylene)m-Ra;
• Y is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclo, aryl or heteroaryl any of which may be optionally independently substituted with one or more Rx groups as allowed by valence;
• Ra is heterocyclo, heteroaryl, —NR3R4, —C(═O)NR3R4;
• —O—R5, —S(O)n—R5, or —S(O)n—NR3R4 any of which may be optionally independently substituted with one or more Rx groups as allowed by valence, and wherein two Rx groups bound to the same or adjacent atom may optionally combine to form a ring;
• R2 is alkyl, cycloalkyl, heterocyclo, aryl, —S(O)nR5, —C(═O)R5, —C(═S)R5, —C(═O)OR5, —C(═S)OR5, —C(═O)NR3R4, —C(═S)NR3R4, —SO2NR3R4, any of which may be optionally independently substituted with one or more Rx groups as allowed by valence;
• R3 and R4 at each occurrence are independently
• (i) hydrogen or
• (ii) alkyl, cycloalkyl, heterocyclo, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkyl, arylalkyl, or heteroarylalkyl any of which may be optionally independently substituted with one or more Rx groups as allowed by valence, and wherein two Rx groups bound to the same or adjacent atom may optionally combine to form a ring;
• or R3 and R4 together with the nitrogen atom to which they are attached may combine to form a heterocyclo ring optionally independently substituted with one or more Rx groups as allowed by valence, and wherein two Rx groups bound to the same or adjacent atom may optionally combine to form a ring;
• R3* and R4* at each occurrence are independently
• (i) hydrogen or
• (ii) alkyl, alkenyl, alkynyl cycloalkyl, heterocyclo, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkyl, arylalkyl, or heteroarylalkyl any of which may be optionally independently substituted with one or more Rx groups as allowed by valence;
• or R3* and R4* together with the nitrogen atom to which they are attached may combine to form a heterocyclo ring optionally independently substituted with one or more Rx groups as allowed by valence;
• R5 and R5* at each occurrence is
• (i) hydrogen or
• (ii) alkyl, alkenyl, alkynyl cycloalkyl, heterocyclo, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkyl, arylalkyl, or heteroarylalkyl any of which may be optionally independently substituted with one or more Rx groups as allowed by valence;
• Rx at each occurrence is independently, halo, cyano, nitro, oxo, alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclo, aryl, heteroaryl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, heterocycloalkyl, -(alkylene)m-OR5, -(alkylene)m-S(O)nR5, -(alkylene)m-NR3R4, -(alkylene)m-C(═O)R5, -(alkylene)m-C(═S)R5, -(alkylene)m-C(═O)OR5, -(alkylene)m-OC(═O)R5, -(alkylene)m-C(═S)OR5, -(alkylene)m-C(═O)NR3R4, -(alkylene)m-C(═S)NR3R4, -(alkylene)m-N(R3)C(═O)NR3R4, -(alkylene)m-N(R3)C(═S)NR3R4, -(alkylene)m-N(R3)C(═O)R5, -(alkylene)m-N(R3)C(═S)R5, -(alkylene)m-OC(═O)NR3R4, -(alkylene)m-OC(═S)NR3R4, -(alkylene)m-SO2NR3R4, -(alkylene)m-N(R3)SO2R5, -(alkylene)m-N(R3)SO2NR3R4, -(alkylene)m-N(R3)C(═O)OR5, -(alkylene)m-N(R3)C(═S)OR5, or -(alkylene)m-N(R3)SO2R5;
• wherein said alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclo, aryl, heteroaryl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, and heterocycloalkyl groups may be further independently substituted with one or more -(alkylene)m-CN, -(alkylene)m-OR5*, -(alkylene)m-S(O)nR5*, -(alkylene)m-NR3*R4*, -(alkylene)mC(═O)R5*, -(alkylene)mC(═S)R5*, -(alkylene)m-C(═O)OR5*, -(alkylene)m-OC(═O)R5*, -(alkylene)mC(═S)OR5*, -(alkylene)m-C(═O)NR3*R4*, -(alkylene)m-C(═S)NR3*R4*, -(alkylene)m-N(R3*)C(═O)NR3*R4*, -(alkylene)m-N(R3*)C(═S)NR3*R4*, -(alkylene)m-N(R3*)C(═O)R5*, -(alkylene)m-N(R3*)C(═S)R5*, -(alkylene)m-OC(═O)NR3*R4*, -(alkylene)m-OC(═S)NR3*R4*, -(alkylene)m-SO2NR3*R4*, -(alkylene)m-N(R3*)SO2R5*, -(alkylene)m-N(R3*)SO2NR3*R4*, -(alkylene)m-N(R3*)C(═O)OR5*, -(alkylene)m-N(R3*)C(═S)OR5*, or -(alkylene)m-N(R3*)SO2R5*;
• n is independently 0, 1 or 2;
• and
• m is independently 0 or 1.