Cd4-mimetic inhibitors of hiv-1 entry and methods of use thereof

A compound of Formula I

• or a pharmaceutically acceptable salt or solvate thereof,
• wherein, independently for each occurrence,
• is optionally substituted aryl or heteroaryl;
• R1is selected from the group consisting of optionally substituted amino,
• R7 is —H, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, hydroxy, optionally substituted alkoxy, optionally substituted amino, or halo;
• R8 is —H, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, hydroxy, optionally substituted alkoxy, optionally substituted amino, or halo;
• or, R7 and R8, taken together, form an optionally substituted five-membered heteroaryl ring or an optionally substituted six-membered aryl or heteroaryl ring;
• m is 1, 2, 3, or 4;
• R is —H, optionally substituted alkyl, hydroxy, optionally substituted alkoxy, optionally substituted amino, or halo;
• and
• n is 0, 1, 2, 3, 4, or 5.

A compound of Formula II

• or a pharmaceutically acceptable salt or solvate thereof,
• wherein, independently for each occurrence,
• is optionally substituted aryl or optionally substituted heteroaryl;
• and
• m is 1, 2, 3, or 4.

A compound of Formula VIII

• or a pharmaceutically acceptable salt or solvate thereof,
• wherein, independently for each occurrence,
• R10 is optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted alkyl, or optionally substituted alkenyl;
• R11 is —H, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, or optionally substituted heteroaryl;
• and
• R12 is optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, or optionally substituted heteroaryl.