1,3-diphenylpropane derivatives, preparations and uses thereof
AssigneeGenfit
InventorsMathieu Dubernet, Jean-Francois Delhomel, Karine Bertrand
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Abstract
The present invention relates to novel 1,3-diphenylpropane derivatives, pharmaceutical compositions comprising the same and therapeutic uses thereof, in particular in the fields of human and animal health. The compounds according to the present invention have intrinsic PPAR agonist properties. They are therefore of particular interest in the treatment of metabolic and/or inflammatory diseases and particularly peripheral and central diseases associated with the metabolic syndrome, such as diverse forms of steatohepatitis, type 2 diabetes, diverse neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease and multiple sclerosis.
Claims19
1-16. (canceled)
A compound, derived from 1,3-diphenylpropane, having the general formula (I):
- in which:
- X1 represents a halogen atom, a hydrogen atom, a R1 or G1-R1 group;
- X2 represents a halogen atom, a hydrogen atom, a R2 or G2-R2 group;
- X3 represents a halogen atom, a hydrogen atom, a R3 or G3-R3 group;
- X4 represents a halogen atom, a hydrogen atom, a R4 or G4-R4 group;
- X5 represents a halogen atom, a hydrogen atom, a R5 or G5-R5 group;
- X6, X7, X9 and X10, identical or different, represent a halogen atom, a hydrogen atom, or an alkyl group;
- X8 represents a G8-R8 group;
- wherein R1, R2, R3, R4 and R5, identical or different, represent an alkyl group, preferably a halogenated alkyl group;
- R8 represents an alkyl group substituted by at least one COOR12 group;
- R12 represents an atom of hydrogen or an alkyl group;
- 01, G2, G3, G4, G5, and G8, identical or different, representing an atom of oxygen or sulfur;
- X11 represents an alkyl group, substituted or not by an aryl or a cycloalkyl group.
Dependencies are inferred from the claim text.