US 2014/0350110 A1Published application

CO-CRYSTALS OF TRAMADOL AND NSAIDs

AssigneeLaboratorios Del Dr. Esteve, S.A.

InventorsHelmut Heinrich BUSCHMANN, Lluis SOLA CARANDELL, Jordi BENET BUCHHOLZ, Jordi Carles CERON BERTRAN, Carlos Ramon PLATA SALAMAN, Nicolas TESSON

Life of this patent

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Abstract

The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.

Claims17

Dependent claims

A co-crystal comprising tramadol either as a free base or as a physiologically acceptable salt and at least one NSAID, wherein the NSAID is naproxen, its enantiomers or salts thereof.

Dependencies are inferred from the claim text.

Facts

Application: 14/324,448Filed 7 Jul 2014
Priority: EP 08384012.417 Oct 2008
Published: 27 Nov 2014
Term ends: Not estimatedThe source records don’t support an estimate.

Classification24 codes

A61K 31/635
Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide: having a heterocyclic ring, e.g.…
A61K 9/16
Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles: agglomerates;…
A61K 31/135
Amines: having aromatic rings , e.g. ketamine, nortriptyline
A61K 31/137
Having aromatic rings , e.g. ketamine, nortriptyline: arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone

Family

Application13/124,027Division · filed 29 Jun 2011
Application14/324,448Division
US 2011/0257134 A1Published application
US 9,393,220 B2Related patent
US 2014/0350110 A1This patent

From the US filing history. Foreign family members aren’t listed.

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