Method for chemical synthesis of antrocin and use thereof for suppressing non-small cell lung cancer
AssigneesYew-Min Tzeng, Zhen Yang
InventorsZhen Yang, Yew-Min Tzeng, Chuang-Chuang Li, Tuo-Ping Luo, Hang Shi, Chi-Tai Yeh
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Abstract
The present invention provides a method for preparing antrocin of pharmaceutically acceptable salts thereof via a series of gold-catalyzed cyclization to construct the (6-6-5) tricyclic core frame. The present invention also provides a use of a composition in preparing drugs for suppressing growth of non-small cell lung cancer cells, wherein the composition comprises an effective amount of antrocin or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier.
Claims28
A method for preparing antrocin, comprising the steps of:
- (a) reacting Compound A
- with sulfide and haloalkane in the presence of a base to produce an intermediate;
- and
- (b) reacting the intermediate with a free radical initiator and a free radical source to form antrocin.
A method for suppressing growth of non-small cell lung cancer cells, comprising administering to a subject in need thereof a composition comprising an effective amount of antrocin or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.