High Concentration Chitosan-Nucleic Acid Polyplex Compositions
AssigneeenGene, Inc.
InventorsEric HSU, Carlos FLEET, Anthony CHEUNG, Jun GAO
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Abstract
The invention provides highly concentrated chitosan-nucleic acid polyplex compositions and dispersions, and methods for producing the compositions and dispersions. Methods of mixing the chitosan-nucleic acid polyplexes include an inline mixing of chitosan solution and nucleic acid solution, followed by further concentrating the dispersion of chitosan-nucleic acid polyplexes, optionally with an aggregation inhibitor. Further provides are methods for altering the diameter of chitosan-nucleic acid polyplexes.
Claims25
A composition, comprising hydrated chitosan-nucleic acid polyplexes, wherein said composition has a nucleic acid concentration greater than or equal to 0.5 mg/ml.
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A pharmaceutical composition, comprising hydrated chitosan-nucleic acid polyplexes, wherein said composition has a nucleic acid concentration greater than or equal to 0.5 mg/ml, and wherein said chitosan-nucleic acid polyplexes comprise a therapeutic nucleic acid construct.
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Dependencies are inferred from the claim text.