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US 2014/0350082 A1Published application
PEPTIDE SEQUENCE DESIGN AND USE THEREOF FOR PEPTIDE-MEDIATED siRNA DELIVERY
AssigneePositec Power Tools (Suzhou) Co., Ltd.
InventorsPu Chen, Mousa Jafari, Wen Xu, Baoling Chen, Ran Pan, Nedra Karunaratne
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Abstract
The invention provides, in one aspect, peptides and a complex comprising one of the peptides and a cargo molecule, wherein the peptide and the cargo molecule are coupled by non-covalently. The peptides of the invention were found to facilitate the delivery of siRNA molecules into cells and to function in siRNA mediated silencing of cellular targets.
Claims21
A complex comprising a peptide having the amino acid sequence according to any one of SEQ ID NOs:
- 1 to 46 and a cargo molecule.
9-11. (canceled)
16-19. (canceled)
A peptide having the amino acid sequence according to any one of SEQ ID NOs:
- 1 to 46.
Dependencies are inferred from the claim text.