Controlling regulatory t cell function

A method of treating an inflammatory condition in a subject, said method comprising:

• selecting a subject with an inflammatory condition and
• administering to the selected subject an agent which enhances Dlgh1 expression, recruitment to the immunological synapse, and/or activity under conditions effective to treat the inflammatory condition.

A method of treating cancer in a subject, said method comprising:

• selecting a subject with a cancer and
• administering to the selected subject an agent which inhibits Dlgh1 protein expression, recruitment to the immunological synapse, and/or activity in CD4+ CD25+ regulatory T cells under conditions effective to treat the cancer.

A method of treating an infectious disease in a subject, said method comprising:

• selecting a subject with an infectious disease and
• administering to the selected subject an agent which inhibits Dlgh1 protein expression and/or activity under conditions effective to treat the infectious disease.

A method of inhibiting regulatory T cell activity, said method comprising:

• administering to the regulatory T cells an agent that inhibits Dlgh1 protein expression under conditions effective to inhibit regulatory T cell activity.