Selective androgen receptor modulators (sarms) and uses thereof
AssigneeLigand Pharmaceuticals Incorporated
InventorLin Zhi
Life of this patent
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Abstract
Provided herein are compounds that bind to androgen receptors and/or modulate activity of androgen receptors. Also provided are methods for making and using such compounds. Also provided are compositions including such compounds and methods for making and using such compositions.
Claims18
A method of treating a subject having a disease, disorder or condition caused by androgen deficiency or hypoactivity or subsensitivity of an androgen receptor or a disease, disorder or condition ameliorated by androgen replacement or responsive to treatment with an AR agonist, comprising:
- administering to the subject a therapeutically effective amount of a compound of formula I;
- wherein:
- R1 is CF3, F or Cl;
- R2 is H or methyl;
- and
- R3 is H or methyl,
- or a pharmaceutically acceptable salt or ester thereof,
- thereby treating the disease, disorder or condition.
A method of treating a subject having a disease, disorder or condition caused by hyperactivity of androgen receptor or a disease, disorder or condition responsive to treatment with an AR antagonist, comprising:
- administering to the subject a therapeutically effective amount of a compound of formula I;
- wherein:
- R1 is CF3, F or Cl;
- R2 is H or methyl;
- and
- R3 is H or methyl,
- or a pharmaceutically acceptable salt or ester thereof,
- thereby treating the disease, disorder or condition.
Dependencies are inferred from the claim text.