Pharmaceutical composition for inhibiting apoptosis of neuron or neurodegeneration

A method for prevention or treatment of a neurodegenerative disease, comprising:

• administering to a subject in need of such prevention or treatment a therapeutically effective amount of a compound of Formula I, a pharmaceutically acceptable salt, an isomer, a solvate, or a hydrate thereof, or any combination thereof:
• wherein R is selected from the group consisting of substituted or unsubstituted C1-C15 arylalkyl, substituted or unsubstituted C1-C15 heteroarylalkyl, and substituted or unsubstituted, linear, branched or cyclic C1-C10 alkyl;
• Y is selected from the group consisting of 0 and —N—R1;
• R1 is at least one selected from the group consisting of —H and linear or branched C1-C3 alkyl;
• R2 is selected from the group consisting of —H and halo;
• A is selected from the group consisting of N, O, and S;
• B is C or N;
• Z is selected from the group consisting of carbamate, —OC(═O)NR3R4, —NH2, —NR5R6, —NC(═NH)NH2, and —NC(═O)NH2;
• each of R3 and R4 is independently selected from the group consisting of C1-C5 alkyl substituted with at least one selected from the group consisting of —H, —NH2 and —NR7R8, unsubstituted C1-C5 alkyl, heterocyclic group substituted with C1-C3 alkyl, and unsubstituted heterocyclic group, or R3 and R4 are taken together to form a 5- or 7-membered heterocyclic group substituted with C1-C5 alkyl or unsubstituted 5- to 7-membered heterocyclic group;
• each of R5 and R6 is independently selected from the group consisting of —H, C2-C3 alkenyl, C2-C3 alkynyl, and linear or branched C1-C7 alkyl unsubstituted or substituted with at least one selected from the group consisting of —OH, —C(O)NH2, C1-C3 alkoxy and carbamate, or R5 and R6 are taken together to form substituted or unsubstituted aliphatic cyclic amine or substituted or unsubstituted aromatic cyclic amine;
• each of R7 and R8 is independently at least one selected from the group consisting of —H and linear or branched C1-C3 alkyl;
• m is an integer in the range of 0 to 4;
• and
• n is an integer in the range of 0 to 5.