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US 2014/0350050 A1Published application
Pyridine compounds as inhibitors of kinase
AssigneeTeligene Ltd.
InventorDawei Zhang
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Abstract
The present invention relates to novel pyridines, their derivatives, pharmaceutically acceptable salts, solvates, entiomers, prodrugs and hydrates thereof. The compounds and compositions of the present invention have protein kinases inhibitory activities and are expected to be useful for the treatment of protein kinases mediated diseases and conditions, including hyper-proliferative disorder, ALK kinases mediated disorder, and neoplasia.
Claims14
1-13. (canceled)
A compound of Formula I:
- or a pharmaceutically acceptable salt, solvate, prodrug or enantiomer thereof, wherein
- R1 is hydrogen, substituted or unsubstituted C1-6 alkyl;
- R2 is hydrogen, substituted or unsubstituted C1-6 alkyl, —C(O)R3 or —C(O)OR3;
- R3 is substituted or unsubstituted C1-6 alkyl;
- with the proviso that R1 and R2 are not both hydrogen, and R1 is substituted or unsubstituted deuterated C1-6 alkyl when R2 is hydrogen.
2 more elements
A compound or its pharmaceutically acceptable salt, or solvate thereof selected from the group consisting of:
- 3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(1-ethylpiperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine;
- N-(3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-yl)acetamide;
- N-(3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-yl)acetamide;
- N-(3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(1-ethylpiperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-yl)acetamide;
- 3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-N-ethyl-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine;
- 3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-N-propylpyridin-2-amine;
- 3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(1-d3-methyl-piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine;
- 3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(1-d5-ethyl-piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine;
- (S)—N-(3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-yl)acetamide;
- (S)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine;
- (S)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(1-d3-methyl-piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine;
- (S)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(1-ethylpiperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine;
- (S)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(1-d5-ethyl-piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine;
- (R)—N-(3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-yl)acetamide;
- (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(1-d3-methyl-piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine;
- (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(1-d5-ethyl-piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine;
- and
- (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(1-ethylpiperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine.
15 more elements
Dependencies are inferred from the claim text.