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US 2014/0350048 A1Published application
Compounds, compositions and associated methods comprising 3-aryl quinolines
AssigneesOregon Health & Science University, The United States of America as represented by the Department of Veterans Affairs
InventorsMichael K. Riscoe, Rolf W. Winter, Sovitj Pou, David J. Hinrichs, Jane Xu Kelly, Yuexin Li, Aaron Nilsen
Life of this patent
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Abstract
Compounds, compositions and methods useful for treating infectious diseases are provided. In particular, 3-aryl quinoline compounds, their synthesis, pharmaceutical compositions thereof and methods of treating infectious diseases such as malaria, are disclosed.
Claims20
A compound with the structure of Formula (II)
- wherein R1 is a substituted alkyl selected from N-isobutylpropanamino, N-isobutylethanamino, N—N-diethylpropanamino, N—N-diethyl-(4-methyl)butanamino, and 2-(2-piperidinyl)ethyl and X1, X2, X3, X4, and X5 are independently selected from at least one of H, halo, alkoxy, ether, alkyl, substituted alkyl, alkyl ether, haloalkyl, haloalkyl ether, aryl, substituted aryl, aryl ether, substituted aryl ether, aryl amine, 5-member heterocycle, 6-member heterocycle, amino, benzylic amide, alkoxy, cyano, morpholinyl, N-ethyl morpholinyl, or carboxyl.
(canceled)
A compound with the structure of Formula (III)
- wherein n is an integer equal to 2 or 3;
- and
- wherein X2, X3, and X4 are independently H, halo, halomethyl, halomethoxy, haloethyl, haloethoxy, phenyl, phenyl ether, halomethoxy substituted phenyl, halomethoxy substituted phenyl ether, dimethylamino, cyano, morpholinyl, or N-morpholinyl ethyl.
Dependencies are inferred from the claim text.